| abstract |
"ADENOSINE RECEPTOR ANTAGONIST ~ 2A ~, AGENT FOR TREATING AND / OR PREVENTING DISEASES, COMPOUND, PHARMACEUTICAL COMPOSITION, AND METHOD FOR TREATING AND / OR PREVENTING DISEASES ASSOCIATED WITH ADENOSINE RECEIVER". An adenosine A 2A receptor antagonist containing as the active ingredient a thiazole derivative represented by a general formula (1), or a pharmacologically acceptable salt of the derivative (where n is an integer from 0 to 3 R¬ 1¬ is substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, a substituted or unsubstituted alicyclic heterocyclic group, or a substituted or unsubstituted aromatic heterocyclic group; R¬ 2¬ is halogen, substituted or unsubstituted lower alkyl substituted or unsubstituted aryl, a substituted or unsubstituted alicyclic heterocyclic group, a substituted or unsubstituted aromatic heterocyclic group, -COR¬ 8¬, or the like; R¬ 3¬ and R¬ 4¬ may be the same or different, and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aralkyl, COR¬ 12¬, etc.) |