| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_35dbc60da9891d57c4047fb7b8689516
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3dc193bc4db0f0b20ad7d96c943225bd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c4afb8b01aa8de7e0b24a86713b23a18 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H23-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-041
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0497
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0482 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H23-00 |
| filingDate |
2004-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_97df0cc575080053b91a1df031097bd9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f0c056b3a51e468adf533a85762f25f9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6bdd29be85a44d2b478054d006c18967
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d39771a2d3f8cde35ddacc66d256808e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_17b3e15ebf75610d2a9f81255c0973fd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_40805d61439f4ec8cf59089220d26c04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_07cc31a4d175a2357606b999ba2e6d52 |
| publicationDate |
2007-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
BR-PI0418010-A |
| titleOfInvention |
cobalamin derivatives useful for diagnosis and treatment of abnormal cell proliferation |
| abstract |
"COBALAMINE DERIVATIVES USEFUL FOR DIAGNOSIS AND TREATMENT OF ANORMAL CELL PROLIFERATION". The present invention relates to cobalamin derivatives (a) that have no binding affinity or have a low binding affinity for transcobalamin transport protein II (TCII) and (b) that retain the activity of vitamin B12 substitutes. optionally carrying a therapeutic and / or diagnostic agent such as a radioactive metal. These compounds have a very low accumulation rate in the blood and benign organs, such as kidney and liver, compared to the accumulation rate in neoplastic tissues, and are more rapidly eliminated from the blood. The present invention also relates to a method for diagnosis and a method for treating a neoplastic disease or microorganism infection in a mammal comprising (a) exposing the mammal to a vitamin B12 free diet period, and ( b) subsequently applying a cobalamin derivative of the present invention carrying a diagnostic agent and / or therapeutic agent. By selecting cobalamin derivatives that act as vitamin B12 substituents, the risk of formation of resistant progeny of neoplastic tissue is greatly reduced. |
| priorityDate |
2003-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |