| abstract |
derivative of indene [2,1a] indene and isoindole [2,1-a] nature, process for the preparation of a compound, pharmaceutical compositions, use of the derivative, use of an identified radiocomposite and method for a preventive treatment or a treatment of disorder. the present invention describes the indene [2, la] indene and isoindole [2,1-a] indole derivatives having formula (i), their salts and their stereo isomers, in which x, r ~ 1 ~, r ~ 2 ~, r ~ 3 ~, r ~ 4 ~, r ~ 6 ~, r ~ 7 ~, r ~ 8 ~, r ~ 9 ~, r ~ 11 ~, r ~ 12 ~, r ~ 13 ~ er ~ 1 ~ are as described in the specification. the invention also provides a method for preparing a compound of formula (1), a pharmaceutical composition containing such compounds and a method for making a medicament. these compounds are useful in the treatment of various CN disorders, hematological disorders, eating disorders, diseases associated with pain, respiratory diseases, chenito-urological disorders, cardiovascular diseases and cancer. |