| abstract |
Cyclic PIRAZOLONE-BASED CYTOKINE INHIBITORS. The present invention relates to 6,7-dihydro-5H-pyrazol [1,2a]. pyrazol-1-ones that inhibit extracellular release of inflammatory cytokines, said cytokines being responsible for one or more disease states in higher humans or mammals. The present invention also relates to compositions containing said 6,7-dihydro-5H-pyrazol [1,2a]. pyrazol-1-ones and methods for preventing, alleviating or otherwise controlling the release of enzymes which are understood to be the active components responsible for the disease states described herein. |