| abstract |
"AZABENZODIAZEPINS AS PHOSPHODIESTERASE-4 INHIBITORS". Compounds of formula (I): wherein: R1 represents a group selected from hydrogen atom, methyl, methoxy, hydroxy, amino, dimethylamino, acetamido, pyrrolidin-1-yl and hydroxymethyl; R 2 represents a group selected from phenyl, pyridyl, pyrimidyl, quinolyl, isoquinolyl, indolyl, pyrolyl, 1,2,2'-triazolyl, benzoyl isoxazolyl, thienyl, pyrazolyl, isothiazolyl, imidazolyl, benzofuranyl, pyrozol ¢ 5.1-c! ¢ 1,2,4! triazyl and each of these groups optionally substituted with from 1 to 3 groups, identical or different, independently of one another, selected from halogen, trifluoromethyl, (C 1 -C 4 alkyl), (C 1 alkoxy) -C4-), hydroxy, amino, acetamido, tert-butyloxycarbonylamino, cycloalkylcarbonylamino, sulfonamide, nitro, acetylmethoxy, cyclopentyloxy; optionally their optical isomers and their addition salts with a pharmaceutically acceptable acid or base, and their use as an active ingredient in a pharmaceutical composition useful for the treatment of diseases involving PDE4 inhibition therapy. |