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publicationDate 2006-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber BR-PI0414814-A
titleOfInvention macrocyclic hepatitis c virus serine ns3 protease inhibitors
abstract "HEPATITE C VIRUS NS3 SERINA PROTEASE MACROCYCLIC INHIBITORS". The present invention describes novel compounds which may have HCV prosthesis inhibitory activity as well as pharmaceutical compositions comprising such compounds and methods of using them to treat HCV protease associated disorders. Novel compounds typically include a 15-20 membered macrocycle and have the general formula (1): wherein Z <39>, L <39>, M <39>, R ~ 1 ~, X and D are defined herein. .
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