http://rdf.ncbi.nlm.nih.gov/pubchem/patent/BR-PI0414446-A

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publicationDate 2006-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber BR-PI0414446-A
titleOfInvention methods for screening for a therapeutic agent, for suppressing the polynucleotide sequence, for treating a non-steroidal cancer, for screening for binding of an agent specifically to a polynucleotide, and for determining whether a patient is at risk for developing or having a non-steroidal cancer, pharmaceutical composition, uses of a therapeutic agent, an antisense molecule or a cell that expresses and / or contains the antisense molecule, at least one of the immunogenic membrane proteins, fragments, derivatives or homologues thereof or from a cell containing and / or expressing at least one of the immunogenic membrane proteins or fragments, derivatives or homologues thereof and an agent or antibody, agent, and kit for identifying a patient at risk of developing or have non-steroidal cancer
abstract "METHODS FOR TRIATING A THERAPEUTIC AGENT, FOR THE SUPPRESSION OF POLYNUCLEOTIDE SEQUENCE, FOR TREATMENT OF A NON-STEROID CANCER, TO CREATE THE CONNECTION OF A SPECIFIC AGENT TO A POLINUCLEOTIDOUS DEVICE HAVE A NON-DEPENDENT STEROID CANCER, PHARMACEUTICAL COMPOSITION, USES OF A THERAPEUTIC AGENT, AN ANTI-SENSE MOLECULE, AND / OR CONTAINS THE ANTI-SENSE MOLLECUS, BY THE FEMNOSES OF THE MENESUS , DERIVATIVES OR APPROVALS OF THESE OR OF A CELL CONTAINING AND / OR EXPRESSING AT LEAST ONE OF THE PROTEINS OF IMMUNOGENIC MEMBRANES OR FRAGMENTS OF THESE AND OF AN AGENT OR ANTIBODY, AGENT, AND, KIT, FOR A RENT DEVELOP OR HAVE A NON-DEPENDENT STEROID CANCER ". The invention relates to agents and methods for the diagnosis, prognosis and treatment of cancer. Specifically, the invention relates to the use of nucleic acid and amino acid sequence encoding transmembrane superfamily member 6 (TM4SF6), protein-like synatopsin (SYPL), 2-like stomaline (STOML2), related GTP-binding protein RAS RAGA), Nucleotide Sensitive Chloride Channel 1A (CLNS1A), Prion Protein (p27-30) (PRNP), Nucleotide Guanine Binding Protein 1 (GNB2L1), Nucleotide Guanine Binding Protein 4 ( GNG4), integral membrane protein 2B (ITM2B), integral membrane protein 1 (ITM1), transmembrane superfamily 9 member 2 (TM9SF2), opiate receptor-like protein 1 (OPRL1), transmembrane receptor-related protein 4 low density lipoprotein (LRP4), human glomerular epithelial protein 1 (GLEPP 1), toll-like receptor 3 (TLR3) and / or translucent zone glycoprotein 3A (ZP3) for the diagnosis of non-steroid specific cancers both early and late stage, cancer prognosis, as well as screening for therapeutic agents that regulate gene expression and / or biological activity of said proteins. This invention further relates to biological technologies designed to inhibit gene expression and / or biological activity of said proteins including the use of screened agents in the screening assays described herein, vector release of antisense polynucleotide sequences and bleaching antibody to said proteins. proteins. In specific embodiments, the proteins are of human origin.
priorityDate 2003-09-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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