Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c76ecadad74a1a35270b3e3a34d60f37 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-505 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
filingDate |
2004-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f398c3becb5bc31a4ad7537b1ae34e48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_96af63bdc389f496c25b028c26f30c1c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d09aabf9599b294e29ee36b607d01453 |
publicationDate |
2018-11-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
BR-PI0414059-B1 |
titleOfInvention |
selective synthesis of cf3 substituted pyrimidines |
abstract |
"selective synthesis of cf3 substituted pyrimidines". The present invention relates to a method of preparing a compound of formula (I) wherein x1-4, x2-4 and r3-4-4-4 are as defined herein. The method includes reacting a compound of formula (ii) with an amine of formula (iii) in the presence of a Lewis acid and a non-nucleophilic base. The 2,4-diaminopyrimidine moiety is a common component in various biologically active drug-like molecules and pyrimidine derivatives have been found to be useful in treating abnormal cell growth, such as cancer, in mammals. |
priorityDate |
2003-09-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |