| abstract |
"BETA-LACTAMASE PROHIBIT INHIBITOR". 6-Beta-hydroxymethylpenicillanic acid sulfone prodrugs of the structure wherein R is H or methyl, each X is methylene and Y is O, or wherein R is H, each X is O and Y are described. methylene, and solvates thereof. Also described are pharmaceutical formulations comprising a prodrug of the present invention, or a solvate thereof, an optional beta-lactam antibiotic and at least one pharmaceutically acceptable carrier. further described is a method for increasing the therapeutic efficacy of a beta-lactam antibiotic in a mammal by administering an effective amount of a beta-lactam antibiotic and an amount for increasing the efficacy of a prodrug of the present invention, or a solvate thereof. Further disclosed is a method of treating a bacterial infection in a mammal by administering a therapeutically effective amount of a pharmaceutical formulation of the present invention to a mammal in need thereof. |