| titleOfInvention |
composition, fusion protein, cdna molecule, vector, recombinant prokaryotic host cell, method for preparing a complement inhibitory molecule, and, uses of a composition and a fusion protein |
| abstract |
complement inhibitor molecule, antibody, fusion protein, nucleic acid molecule, vector, host cell, methods for preparing a complement inhibitor molecule or a functional equivalent or a fusion protein, to identify a ligand of a complement inhibitor molecule , or a functional equivalent, to treat an animal suffering from a complement-mediated disease or disorder, or to prevent an animal from developing a complement-mediated disease or disorder, to vaccinate an animal against a transmitted disease or disorder by a hematophagous arthropod and to inhibit classical and alternative complement pathways in a non-human cell, tissue or organism, composition, use of a complement inhibitory molecule, a fusion protein or a nucleic acid molecule the invention concerns inhibitors complement, which inhibit both the classical and alternative pathways. in particular, the invention relates to complement inhibitors derived from the salivary glands of hematophagous arthropods that inhibit both the classical and alternative complement pathways. the invention also concerns the use of such complement inhibitors in the treatment and prevention of diseases. |