http://rdf.ncbi.nlm.nih.gov/pubchem/patent/BR-PI0410714-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f2d3599fb8f8f479dba95ca9bb504884 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-94 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-88 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-93 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C229-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C229-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-529 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-93 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-94 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-88 |
| filingDate | 2004-05-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8892c8509ad468075576a94c1e2da6b5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a823646737a28a3f1e320b26b803d2fa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_29ed73f3f6e2a48d130acc83e02f0d72 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c68cc4398de264122dc1b34c653392e4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_449003d46338fb1a5ec0c4d43a58b474 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c1d40c63bd36e338dc2ab262a636ac4d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_820d66bb3f1018831decf34157a9ebae http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f810ada851ebd9e65e67e84d913c6fa2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_79015687a1c62ca8327b83ef7d503a56 |
| publicationDate | 2019-09-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | BR-PI0410714-B1 |
| titleOfInvention | MACROCYCLIC QUINAZOLINE DERIVATIVES, THEIR PREPARATION PROCESS, PHARMACEUTICAL COMPOSITION UNDERSTANDING THEM |
| abstract | "quinazoline derivatives". The present invention relates to compounds of the formula: n-oxide forms, pharmaceutically acceptable addition salts and stereochemically isomeric forms thereof, wherein: z represents nh; y represents -C- 3-9-alkyl-, -C- 2-9-alkenyl-, -C- 3-7-alkyl-co-nh optionally substituted by amino, mono- or di (C 1-4 ~ C 1-4 alkyloxycarbonylamino-, C 3-7 alkenyl-co-n- optionally substituted by amino, mono- or di (C 1-4 alkyl) amino- or C 1-4 alkyloxycarbonylamino- 1-4-alkyloxycarbonylamino-, C 1-5-5-alkyl-nr-13-C-1-5-alkyl-, C-1-5-alkyl-nr-14 ^ -co-C-1-5 ~ C 1-6 alkyl-C 1-6 alkyl-C 1-5 alkyl-C 1-6 alkyl-C 1-6 alkyl-C 1- 1-5 alkyl-C 1- 1-3 alkyl nh-co-het ^ 20 ^ -, -c-1-2-alkyl-co-het ^ 21 ^ co-, -c-1-2-alkyl-nh-co-cr ^ 16 ^ r ^ 17 ^ - nh-, -c-1-2-alkyl-co-nh-cr-18 ^ r ^ 19 ^ -co-, -c-1-2-alkyl-co-nr-20 ^ -c-1-3 ~ C1-6 alkyl-co-C1-3-3 alkyl-nh-; x ^ 1 ^ is a direct bond, or O-alkylated or ~ c ~ 1-2; X ^ 2 ^ represents a direct bond, -co-C 1- 1-2-alkyl-, nr ^ 12 ^, - nr ^ 12 ^ -C-1-2-alkyl-, -on = ch- or -c- 1-2-alkyl-; R2 and R2 each independently represent hydrogen or halo; R3 represents hydrogen; R4 is hydrogen or C1-4 alkyloxy; R 12 and R 13 each independently represent hydrogen or C 1-4 alkyl; R 14 and R 15 represent hydrogen; R 16 and R 17 each independently represent hydrogen or C 1-4 alkyl; R 18 and R 19 each independently represent hydrogen or C 1-4 alkyl optionally substituted by phenyl or hydroxy; R 20 and R 21 each independently represent hydrogen or C 1-4 alkyl optionally substituted by C 1-4 alkyloxy; het ^ 20 ^, het ^ 21 ^ and het ^ 22 ^ each independently represent a heterocycle selected from the group consisting of pyrrolidinyl, 2-pyrrolidinonyl or piperidinyl optionally substituted by hydroxy. |
| priorityDate | 2003-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 592.