| abstract |
"2-IMIDAZO-BENZOTIAZOIS AS ADENOSINE RECEIVER CALLS". The invention relates to the 2-imidazo-benzothiazoles of the general formula I, wherein R 1 is phenyl or an N and / or O containing heterocycle; R¬ 2¬ is an imidazole or a null imidazole selected from the group consisting of a), b), c), d) or e), R¬ 3¬ is hydrogen, phenyl, 2,3-dihydro-benzo - ¢ 1,4-dioxin-6-yl, benzo-b-thiophen-3-yl, 3-methyl-benzo-b-thiophen-2-yl, thiophen-2-yl, thiophen-3-yl or thiophen-2-one; ylmethyl, R 4 is hydrogen, - (CH 2 -) - n - O lower alkyl or lower alkyl; R¬5¬ is hydrogen, lower alkyl, halogen, morpholinyl, -NR <39> R <39> <39>, piperidinyl, optionally substituted by hydroxy, or is pyrrolidin-1-yl; R¬ 6¬ is hydrogen, benzyl or - (CH ~ 2 ~) ~ n ~ O-lower alkyl, R¬ 7¬ is hydrogen, -C (O) O-lower alkyl, -C (O) C ~ 6 ~ H ~ 4-halogen, -C (O) -C ~ 6 ~ H ~ 4-lower alkyl, -C (O) lower alkyl, -C (O) cycloalkyl, -C (O) -NR <39 > R <39> <39>, -C (O) - (CH ~ 2 ~) ~ n ~ O-lower alkyl, -S (O) ~ 2 ~ lower alkyl, - (CH ~ 2 ~) ~ n O-lower alkyl, -C (O) -pyridin-4-yl whose ring may be substituted by lower alkyl, halo-lower alkyl or pyrrol-1-yl-methyl, or is (CH-2 ~) -n -C (O) -NR <39> R <39> <39>; R <39> / R <39> <39> are independently from each other hydrogen, lower alkyl or - (CH ~ 2 ~) ~ n-tetrahydropyran-4-yl, X is -CH ~ 2 ~ -, -NR <39><39> <39> - or -O-; R <39> <39> <39> is hydrogen, -C (O) lower alkyl, -C (O) O-lower alkyl, -C (O) -C ~ 6 ~ H ~ 4 ~ CH ~ 3 ~ or benzyl; n is 1 or 2; and to pharmaceutically acceptable acid addition salts thereof. These compounds are adenosine receptor ligands and therefore suitable for the treatment of diseases related to this receptor. |