| abstract |
"Useful Aryl-Substituted Piramide Amide Compounds as Kinase Inhibitors". The present invention relates to compounds having the formula, and pharmaceutically acceptable salts, prodrugs, solvates, isomers and / or hydrates thereof, wherein Q is an optionally substituted phenyl, pyridyl, pyridazinyl, pyrimidinyl or pyrazinyl ring; R 2 is alkyl or an amino group as defined herein; and Z is optionally substituted oxadiazolyl or -C (= O) NR 6 -, where R 6 - is lower alkyl or cyclopropyl. The compounds are surprisingly advantageous in preparing medicaments for treating conditions associated with p38 kinase and / or in preparing medicaments for use in treating inflammatory disorders or conditions in a patient. |