| abstract |
"AZETIDINACARBOXAMIDE DERIVATIVES AND THEIR USE IN THERAPY". The present invention relates to compounds of formula (I) and their use in therapy, particularly for the treatment of a CB-1 ~ receptor-mediated disorder: where R 1 and R 2 are independently selected from aryl. ; and R¬ 3¬ is hydrogen or alkyl; or a pharmaceutically acceptable salt or prodrug thereof, wherein at least one of R¬1¬ and R¬2¬ has a non-hydrogen substituent at their ortho position (s) with respect to the point of attachment with the group ¢ -CH-0- !. |