| abstract |
"CARBOXYLIC ACIDS REPLACED WITH PHENYL". Pharmaceutically acceptable compounds and salts of formula (A) are disclosed which are useful in the treatment of metabolic disorders related to insulin resistance, leptin resistance, or hyperglycemia. Compounds of the invention include Protein tyrosine phosphatase inhibitors, in particular Protein tyrosine phosphatase-1B (PTP-1B), which are useful in the treatment of diabetes and other PTP-mediated diseases, such as cancer, neurodegenerative diseases and the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods for treating the conditions mentioned above using said compounds. |