| abstract |
"PYRIMIDINONES AND PYRIMIDINIONS REPLACED AS CRF ANTAGONISTS". This invention relates to substituted pyrimidinone and substituted pyrimidinothione derivatives which bind with high affinity to CRF-1? Receptors, including human CRF-1? Receptors. This invention also relates to methods of using compounds of the invention to treat a disorder or condition, the treatment of which may be affected or facilitated by antagonizing a CRF receptor, such as CNS disorders or disorders, particularly anxiety disorders, and depression and stress-related disorders. |