| abstract |
"Isochromic Compounds Replaced for the Treatment of Metabolic Disorders, Cancer and Other Diseases." The present invention relates to novel heterocyclic compounds whose structure corresponds to formula (I), wherein the Ar-1 ~ radicals are substituted isochromanic radicals, the Ar-2 ~ radicals are aryl or heteroaryl radicals, and HAr is a 2,4-thiazolidinedione or 2-thioxo-imidazolidin-4-one, 2,4-imidazolidinedione or 2-thioxo-imidazolidine-4-one radical. The compounds of formula (I) may have a biological activity which advantageously controls carbohydrate metabolism, including serum glucose levels, and lipid metabolism, and may be used for the treatment of hyperlipidemia and / or hypercholesterolemia, and Type 11 diabetes. The compounds of formula (I) may also be used to treat uncontrolled proliferation disorders, including cancer. |