| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_645019633c6b8a4aedc693f719ac8c7e |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5031
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-62 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5031
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-62 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K-
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00 |
| filingDate |
2004-04-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9c9ed7b23b0baa18b0a862ce509815c5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5089fe9371a9c4c8563a30fcc7ac91b5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7985b4b62136fb0554192cbceecd4eed
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3977fbd6338b562ceb08dcf421ec8200 |
| publicationDate |
2006-04-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
BR-PI0409322-A |
| titleOfInvention |
method for preparing site-specific protein conjugates |
| abstract |
"METHOD FOR PREPARING SITE-SPECIFIC PROTEIN CONJUGATES". The invention relates to a single step method for rapidly and efficiently preparing protein-polymer conjugates, including an insulin-polymer conjugate. In accordance with the method of the present invention, a hydrophilic protein and polymer are contacted in the presence of at least one organic solvent and at least one metal chelator under conditions that promote the formation of a protein and polymer conjugate. Thus, the invention is directed to site specific modification of selected proteins, such as insulin, with poly (ethylene glycol) in the PheB1 residue. The invention also provides a pharmaceutical formulation for encapsulating the conjugate in a biodegradable polymer. |
| priorityDate |
2003-04-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |