abstract |
"COMPOUND; PHARMACEUTICAL COMPOSITION; METHOD FOR TREATING IKK-MEDIATED DISEASE AND METHOD FOR INHIBITING IKK IN A PATIENT YOU NEED". This invention provides beta-carboline compounds of formula I: wherein Ring A is a pyridinyl, pyrimidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl, pyranyl, tetrahydrofuranyl, cyclohexyl, cyclopentyl or thiomorpholinyl ring, and R¬ 1¬ , R¬ 2¬ and R¬ 3¬ are as described in the descriptive report. The compounds are inhibitors of IKK-2, which are useful for treating IKK-2 mediated diseases, such as inflammatory diseases and cancer. |