| titleOfInvention |
compound, process for the manufacture thereof, composition, process for the manufacture thereof, method of treating or preventing a protein kinase-mediated disorder in an individual, use of a compound, assay to determine the activity of the compounds, and method inhibiting the activity or function of a protein kinase |
| abstract |
"COMPOUND, PROCESS FOR MANUFACTURING THE SAME, COMPOSITION, PROCESS FOR MANUFACTURING THE SAME, METHOD OF TREATMENT OR PREVENTION OF A PROTEIN MEDIATED KINASE IN AN INDIVIDUAL, USE OF A COMPOUND, TEST FOR, AND THE DETERMINATION OF, AND THE DETERMINATION OF, METHOD OF INHIBITING THE ACTIVITY OR FUNCTION OF A PROTEIN KINASE ". The Pyrazol 1,5-α-pyrimidine derivatives represented by formula I and their pharmaceutically acceptable salts exhibit excellent kinase inhibiting activity. It is therefore expected that drugs comprising the compounds as effective ingredients will be useful as therapeutic or prophylactic agents for a protein kinase-mediated disorder in which kinase is implicated such as inflammatory disease, autoimmune disease, destructive bone disorder, cancer and / or tumor growth. |