| abstract |
"D-HOMOESTRA-1,3,5 (10) -TRIEN-3-ILA 2-REPLACEMENTS OF ANTI-TUMOR ASSETS". The invention relates to 2-substituted D-homoestra-1,3,5 (10) -trien-3-yl sulfamates of the general formula (I), wherein R¬ 3¬ is C 1 -C 1 -5 alkyl or a C 1 -C 5 alkyloxy group and the use thereof for the production of a drug for curing tumor diseases which may be positively influenced by inhibition of tubulin polymerization. The compounds of the invention are characterized by a D-homosubstitution, particularly for their effect to inhibit tubulin polymerization and in which they can be used, for example, to cure prostate carcinomas. |