| abstract |
"therapeutic polypeptides, their counterparts, their fragments, which are used in modulations of platelet aggregation." The present invention relates to polypeptides comprising at least one single domain antibody is directed against vwf, the vwf a1 domain, the activated vwf a1 domain, the vwf a3, gplb and / or collagen domain, homologues of said polypeptides, and / or functional parts of said polypeptides, for pathological treatment requiring modulation of platelet aggregation and overcoming the prior art problems. A further aspect of the invention is to provide a method for producing said polypeptides, a method for coating devices with such polypeptides used in medical procedures (e.g., PCTA, expandable stent insertion), methods and kits for selecting platelet aggregation modulating agents and kits. to diagnose platelet aggregation related diseases. |