| abstract |
"protein complex using an immunoglobulin fragment and method for preparing it". The present invention relates to a protein conjugate of improved duration and stability in vivo and use thereof. the protein conjugate includes a physiologically active polypeptide, a nonpeptide polymer and an immunoglobulin fragment fc. Since all three components are covalently linked, the protein conjugate has extended duration and enhanced stability for the physiologically active polypeptide. The protein conjugate maintains in vivo activity at relatively high levels and markedly increases serum half-life for the physiologically active polypeptide, with less risk of inducing unwanted immune responses. Thus, the protein conjugate is useful for developing long-acting formulations of various polypeptide drugs. |