| abstract |
"cyclodextrin-based polymers for the supply of therapeutic agents linked to them by covalence". the present invention relates to novel compositions of therapeutic polymeric compounds containing cyclodextrin designed as a vehicle for the supply of small molecule therapeutic substances and pharmaceutical compositions thereof. more specifically, therapeutic / bioactive agents are covalently linked to polymers containing cyclodextrin. these cyclodextrin-containing polymers improve the stability and solubility of the drug and reduce the toxicity of the small molecule therapeutic agent when used in vivo. moreover, selecting from a variety of linker and targeting binder groups, the polymers present methods for the controlled delivery of therapeutic agents. the invention also relates to processes for treating patients with the therapeutic compositions described herein. the invention also relates to processes for conducting the pharmaceutical business comprising manufacturing, licensing or distribution kits containing or related to the polymeric compounds described herein. |