| abstract |
compound, prodrug, pharmaceutical composition, composition and method for modulating calcium receptor, method for preventing or treating bone diseases, and use of the compound or a salt thereof or a prodrug thereof. A calcium receptor modulator is provided which comprises a compound of formula (I): wherein ring a is an optionally substituted 5 to 7 membered ring; ring b is an optionally substituted 5 to 7 membered heterocyclic ring; x ^ 1 ^ is cr ^ 1 ^, cr ^ 1 ^ r ^ 2 ^, n or nr ^ 13 ^; x ^ 2 ^ is n or nr ^ 3 ^; y is c, cr ^ 4 ^ or n, z is cr ^ 5 ^, cr ^ 5 ^ r ^ 6 ^, n or nr ^ 7 ^; ar is an optionally substituted cyclic group; r is h, an optionally substituted hydrocarbon group, etc. and - - - is a single bond or a double bond; r ^ 1 ^, r ^ 2 ^, r ^ 3 ^, r ^ 4 ^, r ^ 5 ^, r ^ 6 ^, r ^ 7 ^ and r ^ 13 ^ are independently h, an optionally substituted hydrocarbon group or a salt thereof or a prodrug thereof. the compounds of formula (ii) and (iii): wherein ring a is an optionally substituted 5 to 7 membered ring; q is c, cr ^ 5 ^ or n; R 8, R 9, R 10, R 11 and R 12 are independently an optionally substituted hydrocarbon group, etc., or a salt thereof are also provided. x ^ 1 ^, r ^ 3 ^, r ^ 1 ^, y and x ^ 3 ^ are also specified in formula (ii) and (iii) as before. |