| abstract |
"growth hormone release peptides". The present invention relates to peptides and peptidomimetic compounds generally according to formula (I), and pharmaceutically acceptable salts thereof, which are useful as ghrp analogs: R ^ 1 ^ -a ^ 2 ^ -a ^ 3 ^ - a ^ 4 ^ a ^ 5 ^ -r ^ 2 ^ (i) or a pharmaceutically acceptable salt thereof, wherein: a ^ 1 ^ is alb, apc or lnp; a ^ 2 ^ is d-bal, d-beep, d-bpa, d-dip, d-1nal, d-2nal, d-ser (bzl) or d-trp; Î ± 3 is d-bal, d-beep, d-bpa, d-dip, d-1 nal, d-2nal, d-ser (bzl) or d-trp; Î ± 4β is 2fua, orn, 2pal, 3pal, 4pal, pff, phe, pim, taz, 2thi, 3thi, thr (bzl); a ^ 5 ^ is apc, dab, dap, lys, orn or deleted; R1 is hydrogen, (C 1-6) alkyl, (C 5-14) aryl, (C 1-6) alkyl (C 5-14) aryl, C 3 (8) cycloalkyl or (C 2-10) acyl; and r ~ 2 ~ is oh or nh ~ 2 ~; and pharmaceutical compositions and methods for their use. |