| abstract |
"Imidazole compounds fused to aryl or heteroaryl as anti-inflammatory and analgesic agents". this invention provides a compound of formula (I): or pharmaceutically acceptable salts thereof, wherein Y1 , Y2 , Y3 , and Y4 are independently selected from n , Ch , etc. ; R1 is C1-8 alkyl, etc.; q1 is a 512-membered aromatic monocyclic or bicyclic ring, optionally containing up to 4 heteroatoms selected from o, n and s, etc.; a is a 5-6 membered monocyclic aromatic ring, optionally containing up to 3 heteroatoms selected from o,n and s, etc.; b is a C 1-6 alkylene optionally substituted with an oxo group, etc.; w is nh, o, etc.; R2 is h, C1-4 alkyl, etc.; z is a 5-12 membered monocyclic or bicyclic aromatic ring, optionally containing up to 3 heteroatoms selected from o, n and s, etc.; 1 is halo, C1-4 alkyl, etc.; m is 0, 1 or 2; R3 and R4 are independently selected from H and C1-4 alkyl; R5 is H, C1-4 alkyl, etc.; q2 is a 5-12 membered aromatic monocyclic or bicyclic ring, optionally containing up to 3 heteroatoms selected from o, n and s, etc. these compounds are useful for the medical treatment of conditions mediated by prostaglandin, such as pain, fever or inflammation, etc. this invention also relates to a pharmaceutical composition including the above compound. |