| abstract |
"indazole compounds, pharmaceutically acceptable prodrug, pharmaceutically active metabolite, or pharmaceutically acceptable salt, pharmaceutical compositions, method for treating a protein kinase activity-mediated disease condition of a mammal and method for modulating receptor activity" protein kinase ". Indazole compounds that modulate and / or inhibit the activity of certain protein kinases are described. Such compounds and the pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction, and thereby modulating and / or inhibiting unwanted cell proliferation. The invention also relates to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds and methods of treating cancer and other disease states associated with unwanted angiogenesis and / or cell proliferation, such as diabetic retinopathy, neurovascular glaucoma. rheumatoid arthritis and psoriasis by administering effective amounts of such compounds. |