| abstract |
Invention Patent: <B> "BENZISOXAZOLES AND PHENONES AS ALPHA ~ 2 ~ -Antagonists" <D>. The present invention relates to compounds of the formula (I), the N-oxide forms, the pharmaceutically acceptable addition salts and their stereochemically isomeric forms, wherein Alq is C ~ 5-12 ~ alkanediyl; n is 1 or 2; p is 1 and q is 2; or p is 2 and q is 1; X is -O-, -S-, -S (= O) -, -S (= O) ~ 2 ~ - or NR ^ 2 ^; each R1 + 1 is independently hydrogen, halogen, C ~ 1-6 ~ alkyl, nitro, hydroxy or C ~ 1-4 ~ alkyloxy; R 2 is hydrogen, C ~ 1-6 ~ alkyl, aryl or C ~ 1-6 ~ alkyl substituted with aryl; aryl is phenyl or phenyl substituted with an halogen or C ~ 1-6 ~ alkyl; D is optionally substituted benzophenone or 3-benzisoxazolyl; which has central <244> ~ 2 ~ -adrenoceptor antagonistic activity. It additionally refers to its preparation, use and pharmaceutical compositions. |