| abstract |
"PYRIDINE COMPOUND COMPOSITION, PROCESSES FOR PREPARING PYRIDINE COMPOUND COMPOSITION AND PARENTAL FORMULATION, USE OF A COMPOSITION, PHARMACEUTICAL COMPOSITION TO TREAT DIABETIC COMPLICATIONS AND DISEASES FOR HEALTH AND ASSOCIATED DISEASES PREVENT OR TREAT DISEASES CAUSED BY DIABETES AND AGING COMPLICATIONS ". The invention describes pyridinium series compounds useful for treating vascular complications associated with aging and diabetes and, particularly for the treatment of complications associated with diabetes mellitus as well as other aging related conditions including renal diseases, nerve changes, atherosclerosis, retinopathy, dermatological conditions and tooth discolouration by fragmentation of the preformed AGE of formula I or pharmaceutically acceptable salts thereof, where R 1, R 2, and X are as defined. in the descriptive report. The invention also describes a method for preparing the compounds of this series and pharmaceutical compositions having one or more compounds as defined above as active ingredients. The invention further describes a method for treating diabetic patients by administering the compounds in the manner described above, either individually or in combination with the other diabetes therapy medicaments. |