| abstract |
"PHARMACEUTICAL COMPOSITIONS CONTAINING POLY (ADP-RIBOSE) GLICOHYDROLASE INHIBITORS AND METHODS FOR USE". The present invention relates to pharmaceutical compositions containing poly (ADP-ribose) glycohydrolase inhibitors, also known as PARG inhibitors, and methods of their use to inhibit or reduce free radical-induced cellular energy depletion, cell damage or death. More particularly, the present invention also relates to pharmaceutical compositions containing poly ADP-ribose glycohydrolase inhibitors such as glucose derivatives: lignin glycosides; hydrolysable tannins including galotanine and elagitanine; adenoside derivatives; acridine derivatives including 6,9-diamino-2-ethoxycridine lactate monohydrate; tilorone analogs including tilorone R10 556, daunomycin or daunorubicin hydrochloride; ellipticine; proflavine and other PARG inhibitors and their methods of use in the treatment and prevention of diseases or conditions relating to free radicals that induce cell energy depletion and / or tissue damage resulting from cell damage or death due to necrosis, apoptosis or combinations thereof. |