| abstract |
"NON-PEPTIDIC GnRH COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHODS FOR REGULATING GONADOTROPIN SECRETATION IN MAMMALS" <D> Non-peptide GnRH agents that are capable of inhibiting the effect of the gonadotropin releasing hormone are described. Such compounds and their salts, multimers, multimers, prodrugs and pharmaceutically acceptable active metabolites are suitable for the treatment of reproductive disorders in mammals and steroid hormone-dependent tumors, as well as for regulating fertility, where suppression of gonadotropin release is indicated. Methods for synthesizing compounds and intermediates useful in their preparation are also described. |