| abstract |
Invention Patent: <B> "HETEROCYCLIC COMPOUNDS AS ROTAMASE ENZYME INHIBITORS" <D>. Compounds of the formula (I): where A is C-3 ~ -C ~ 5 ~ alkylene unbranched optionally substituted by C ~ 1 ~ -C ~ 6 ~ alkyl; X is O, S, NH or N (C ~ 1 ~ -C ~ 6 ~ alkyl); Y is O, S, NH or N (C ~ 1 ~ -C ~ 6 ~ alkyl); R is a heterocyclic group, non-aromatic, in a 4- to 6-membered ring, linked in C, which contains a nitrogen heteroatom, said group being optionally substituted by 1, 2 or 3 substituents each independently selected from C ~ alkyl 1 ~ -C ~ 6 ~, C ~ 2 ~ -C ~ 6 ~ alkenyl, C ~ 3 ~ -C ~ 7 ~ cycloalkyl, aryl, het, -CO ~ 2 ~ - (C ~ 1 ~ -C ~ 6 alkyl ~), -CO (het), -CONR ^ 5 ^ R ^ 6 ^ and -CO (aryl), said alkyl and alkenyl being optionally substituted by 1 or 2 substituents each independently selected from C ~ 3 ~ -C cycloalkyl ~ 7 ~, aryl, het, -O (aryl), -O (C ~ 1 ~ alkylene ~ 2 ~) aryl, -CO (het), -CONR ^ 5 ^ R ^ 6 ^ and -CO (aryl ); are inhibitors of Rotamase enzymes, in particular FKBP-12 and FKBP-52. The compounds, therefore, moderate neuronal regeneration and bulge and can be used for the treatment of neurological disorders arising from neurodegenerative diseases or other disorders involving nerve damage. |