| abstract |
Invention Patent: <B> '' THERAPEUTIC COMBINATIONS OF ESTROGEN RECEIVER (SELECTIVE) MODULATORS (SERM) AND GROWTH HORMONE (GHS) SECRETAGOGUES FOR TREATING MUSCLE-SKELETAL FRAGILITY '' <D>. This invention relates to pharmaceutical combination compositions and methods containing (-) - cis-6-phenyl-5- (4- (2-pyrrolidin-1-yl-ethoxy) -phenyl) -5,6,7 , 8-tetrahydronaftale n-2-ol or a pharmaceutically acceptable salt thereof and 2-amino-N- (2- (3a (R) -benzyl-2-methyl-3-oxo-2,3,3a, 4,6,7-hexahydro-pyro zolo- [4,3-c] pyridin-5-yl) -1- (R) -benzyloxymethyl-2-oxo-ethyl) -iso-butyramide or a pharmaceutically acceptable salt thereof , methods for using such compositions and kits containing such compositions. The compositions are useful for the treatment of musculoskeletal fragility, including osteoporosis, osteoporotic fracture, weak bone mass, fragility and weak muscle mass. |