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filingDate 1999-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2001-02-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber BR-9910967-A
titleOfInvention Poly (adp-ribose) polymerase homolog, binding partner for parp homologs, nucleic acid, expression cassette, recombinant vector, recombinant microorganism, transgenic mammal, parp deficient mammal or parp deficient eukaryotic cell, processes for in vitro detection for parp inhibitors, in vitro screening for binding partners for a parp molecule, for the qualitative or quantitative determination of nicléic acids encoding a parp homolog, for the qualitative or quantitative determination of a parp homolog, for determining the efficacy of parp effectors, gene therapy composition, pharmaceutical composition, and use of low molecular weight parp binding partners
abstract "POLY HOMOLOGIST (ADP-RIBOSE) POLYMERASE, BINDING PARTNER FOR HOMOLOGISTS OF PARP, NUCLEIC ACID, EXPRESSION CASSETTE, RECOMBINANT VECTOR, RECOMBINANT MICROORGANISM, TRANSGENIC EMPHASIS, EMPHASIC EMPHASIS, MULTIPLE PHARMACEUTICAL MAMPHEROUS, EMPHASIS IN VITRO FOR PARP INHIBITORS, IN VITRO SCREENING FOR PARTNERS CONNECTING TO A PARP MOLECULE, FOR QUALITATIVE OR QUANTITATIVE DETERMINATION OF NUCLEIC ACIDS, CODING A PARP HOMOLOGOUS, QUALITATING HOMATOMINATING DETERMINING THE EFFECTIVENESS OF PARP EFFECTORS, GENE THERAPY COMPOSITION, PHARMACEUTICAL COMPOSITION, AND, USE OF LOW MOLECULAR WEIGHT PARP BINDING PARTNERS "The invention concerns poly (ADP-ribose) -polymerase (PARP) counterparts are characterized by an amino acid sequence with a) a functional NAD ^ + ^ binding site and b) no zinc of general formula CX ~ 2 ~ CX ~ m ~ HX ~ 2 ~ C, where m is an integer 28 or 30 and the radicals X represent any amino acid, independently of each other, and to the functional equivalents of said poly homologs (ADP-ribose) -polymerase (PARP). The invention also concerns nucleic acids encoding poly (ADP-ribose) -polymerase (PARP) homologs, antibodies with specificity for the new protein, pharmaceutical and gene therapy agents containing the products of the invention, processes to analytically determine the proteins and nucleic acids of the invention, to processes to identify the effectors or binding partner of the inventive proteins, to new PARP effectors and to processes to determine the efficacy of such effectors.
priorityDate 1998-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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