abstract |
Invention Patent: <B> "BENZOXAZINONES / BENZOTIAZINONES AS SERINE PROTEASE INHIBITORS" <D>. The present invention relates to benzoxazinone and benzothiazinone compounds, which have inhibitory effects on serine proteases such as factor Xa, thrombin and / or factor VIIa. The invention also relates to pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic agents for the treatment or prevention of disease states in mammals characterized by abnormal thrombosis. |