abstract |
"MICRO-ORGANISM, AND, PROCESS TO PRODUCE A PURINE NUCLEOSIDE BY FERMENTATION" A microorganism that has a gene encoding an enzyme in which the inhibition of backfeed is desensitized by replacing one or two amino acids in PRPP amidotransferase encoded by Escherich purf. coli, a gene encoding a protein that is an inactivated repressor of purR-encoded purine nucleoside biosynthesis, one genetically encoding an enzyme that is deoD-encoded inactivated purine phosphorylase, a gene encoding an enzyme that is succinyl synthase PurA inactivated AMP, a gene encoding an enzyme that is edd-inactivated 6-phosphogluconate dehydrase, a gene encoding an enzyme that is pgi-encoded inactivated phosphoglucose isomerase and the like, is created and a purine nucleoside is produced by cultivation of the microorganism. |