http://rdf.ncbi.nlm.nih.gov/pubchem/patent/BR-9813926-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c76ecadad74a1a35270b3e3a34d60f37 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-416 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-06 |
| filingDate | 1998-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3c131c45399d8659e827ade08975dd44 |
| publicationDate | 2000-09-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | BR-9813926-A |
| titleOfInvention | Replacement of catechol bioisomer with indazole in therapeutically active compounds |
| abstract | Invention Patent: <B> "REPLACEMENT OF CATECOL BIOISTERER BY INDAZOL IN THERAPEUTICALLY ACTIVE COMPOUNDS" <D>. Therapeutically active material compositions and their member species are described, comprising compounds containing indazole, in which said compounds and their pharmaceutical activity result directly from a replacement of catechol-by-indazole bio-ester of a compound containing catechol having the same therapeutic activity. , where said non-catechol substituents are the same or homologous before and after said substitution, wherein said compositions of matter comprise a compound of Formula (I¹) or (I²): or a pharmaceutically acceptable salt thereof, wherein in a preferred embodiment R ^ C ^ represents hydrogen; R ^ A ^ represents cyclohexyl; and R ^ B ^ represents ethyl. R ~ a ~ and R ~ b ~ each represent, independently and independently, hydrogen or non-catechol substituents of said compounds, which result directly from a catechol-by-indazole bioisoster substitution of said catechol-containing compound having said activity therapeutics, where said non-catechol substituents are the same or homologous before and after said replacement, provided that R ~ a ~ and R ~ b ~ cannot represent both at the same time, hydrogen. The therapeutic activity involved may comprise cholinesterase inhibitory activity, <244> ~ 1 ~ -antagonist and <225> ~ 1 ~ -adrenergic activity, calcium channel inhibitory activity, antineoplastic activity, and type IV phosphodiesterase inhibitory activity. |
| priorityDate | 1997-11-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 32.