| abstract |
Invention Patent "NEW DERIVATIVES FROM TAXAN". The present invention relates to the Taxane derivatives, represented by the formula (1): [where, A¹ represents a group (formula of line 5) (in which R¹ represents an H, or a (substituted alkyl group) or a group (Formula of line 7) (in which R² represents an amine group, a mono- or di-alkylamine group, a piperidine group, a pyrolidine group or a morpholino group), X represents an H, an alkoxycarbonyl group, or a benzoyl group, Y represents H or a trialkylsilyl group, A² represents a furyl group, an alkylfuryl group, an alkyl group or a fluorophenyl group, Ac represents an acetyl group, and Bz represents a benzoyl group] or salts thereof; and drugs containing the same as an active ingredient. These compounds have excellent water solubility and anti-tumor activity. |