| abstract |
Invention Patent: <B> "CERTAIN 5-ALKYL-2-ARYLAMINOPHENYLACETIC AND DERIVED ACIDS" <D>. Compounds of formula I are described in which R is methyl or ethyl; R ~ 1 ~ is chlorine or fluorine; R ~ 2 ~ is hydrogen or fluorine; R ~ 3 ~ is hydrogen, fluorine, chlorine, methyl, ethyl, methoxy, ethoxy or hydroxy; R ~ 4 ~ is hydrogen or fluorine; and R ~ 5 ~ is chlorine, fluorine, trifluoromethyl or methyl; the pharmaceutically acceptable salts thereof; and the pharmaceutically acceptable prodrug esters thereof; as selective inhibitors of COX-2 cyclooxygenase. |