http://rdf.ncbi.nlm.nih.gov/pubchem/patent/BR-9811554-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a86df80eda1b7a997e80056f0e367c65 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-83 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-83 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D407-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-35 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-343 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 |
| filingDate | 1998-07-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a9bcb2ffeb6f85dd0640719bb14ea1a1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5df6eac88be6e7aa7660b7b4959bf58d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a861486c4f60f419d82d0917228d55a4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_afa2bf97500aada4e362807eb0b18c79 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0baa8de5165921d36ae136dc8b095520 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_765d18d62c77347c46777b9610549dc1 |
| publicationDate | 2000-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | BR-9811554-A |
| titleOfInvention | Replaced aurona derivatives |
| abstract | Invention Patent: <B> "SUBSTITUTED AURONA DERIVATIVES" <D>. a method for treating a microbial infection is described. The method includes administering to a patient a pharmaceutical composition containing a compound of formula (IA) where each R is independently H, OH, Br, CI, I, amino, thiol, nitro, C ~ 1-4 ~ alkoxy, C ~ 1 -4 ~ alkenyloxy, C ~ 2-6 ~ alkoxyalkyleneoxy, C ~ 1-4 ~ alkylthio, C ~ 3-18 ~ alkyl or C ~ 3-18 ~ alkenyl; or two adjacent Rs, taken together, are a divalent C ~ 2-18 ~ portion containing at least one oxygen atom, substituted or disubstituted with A or B or both, A being H, OH, Br, Cl, l, amino or thiol and B being H, C ~ 1-10 ~ alkyl, C ~ 2-18 ~ alkenyl or C ~ 6-18 ~ aryl; as long as at least two Rs are not H; with the additional proviso that when each of the two Rs is one of OH, C ~ 1-4 ~ alkoxy, C ~ 1-4 ~ alkenyloxy or C ~ 2-6 ~ alkoxyalkyleneoxy and X is phenyl substituted with two independently selected substituents of OH, alkoxy and alkenyloxy, the remaining R cannot be prenyl; with the additional proviso that when each of the two Rs is one of OH, C ~ 1-4 ~ alkoxy, C ~ 1-4 ~ alkenyloxy or C ~ 2-6 ~ alkoxyalkyleneoxy and X is phenyl substituted with three independently selected substituents of OH, alkoxy and alkenyloxy, the remaining R cannot be prenyl, with the additional condition that when each of the two Rs is one of OH, C ~ 1-4 ~ alkoxy, C ~ 1-4 ~ alkenyloxy or C ~ 2-6 ~ alkoxyalkyleneoxy and X is phenyl substituted with a prenyl substituent and with two additional substituents independently selected from OH, alkoxy and alkenyloxy, the remaining R cannot be H or OH; with the additional proviso that when each of the two Rs is one of OH, C ~ 1-4 ~ alkoxy, C ~ 1-4 ~ alkenyloxy or C ~ 2-6 ~ alkoxyalkyleneoxy and X is phenyl substituted with a substituent containing three rings and with two additional substituents independently selected from OH, alkoxy and alkenyloxy, the remaining R cannot be prenyl; X is C ~ 4-10 ~ alkyl, C ~ 4-20 ~ alkenyl or a portion of simple C ~ 4-20 ~ ring, C ~ 6-20 ~ bridged or C ~ 6-20 ~ molten containing cycloalkyl, cycloalkenyl , aryl, heterocyclyl or heteroaryl, where X is substituted with H, OH, Cl, Br, 1, amino, cyano, nitro, alkyl, alkoxy, alkenyl or alkenyloxy; as long as if X is a heteroaryl or heterocyclyl moiety where two of R are each OH and target each other, then the remaining R is H and ortho for each of the two hydroxyls, Y and Z are each O, and one ring atom of X is attached directly to the carbon atom sp adjacent to X, then replaced with H, OH, Cl, Br, I, amino, cyano, alkyl, alkoxy, alkenyl or alkenyloxy; and each of Y and Z is independently selected from O, S and NH; or a pharmaceutically acceptable salt or ester thereof. |
| priorityDate | 1997-07-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 32.