| abstract |
Invention Patent: <B> "6-AZAURACYL DERIVATIVES AS IL-5 INHIBITORS" <D>. The present invention relates to the use of compounds of formula (I), their N-oxides, their pharmaceutically acceptable addition salts and their stereochemical isomeric forms in which p represents 0.1,2 or 3, q represents 0.1, 2.3 or 4; R¹ represents hydrogen, C ~ 1-6 ~ alkyl, mono- or di (C ~ 1-6 ~ alkyl) aminoC ~ 1-6 ~ alkyloxy, mercapto, C ~ 1-6 ~ alkylthio, C ~ 3-7 ~ cycloalkyl , aryl or C ~ 1-6 ~ alkyl substituted by mono- or di (C ~ 1-6 ~ alkyl) amino, C ~ 1-6 ~ alkyloxy, aryl or Het; R² represents cyano, or a radical of the formula -C (= X) -Y-R ^ 5 ^; where X represents O or S; Y represents O, S, NR ^ 6 ^ or a direct bond; R ^ 5 ^ represents hydrogen, C ~ 3-7 ~ cycloalkyl, aryl or optionally substituted C ~ 1-6 ~ alkyl, and where Y is a direct bond, R ^ 5 ^ can also be halo or Het; each of R³ and R ^ 4 ^ independently represent halo, haloC ~ 1-6 ~ alkyl, C ~ 1-6 ~ alkyl, hydroxy, C ~ 1-6 ~ alkyloxy, C ~ 1-6 ~ alkylcarbonyloxy, mercapto, C ~ 1-6 ~ alkylthio, C ~ 1-6 ~ alkylsulfonyl, C ~ 1-6 ~ alkylsulfinyl, haloC ~ 1-6 ~ alkylsulfonyl, aryl, cyano, nitro, amino, mono- and di (C ~ 1-6 ~ alkyl) amino or (C ~ 1-6 ~ alkylcarbonyl) amino; aryl represents phenyl, or substituted phenyl; and Het represents an optionally substituted heterocycle; in the production of a drug useful in the treatment of eosinophil-dependent inflammatory diseases. The invention also relates to new compounds, their preparations and compositions containing them. |