| abstract |
"3-OXADIAZOLYL-1,6-NAFTIRIDIN-2 (1H) -ONA-5-REPLACED DERIVATIVES" New 3-oxadiazolyl-1,6-naphthyridine-2 (1H) -one-5-substituted derivatives represented by the formula general (I), where Het represents oxadiazolyl, R ^1 ^ represents H, lower alkyl, lower cycloalkyl, lower alkenyl, lower alkoxy, optionally substituted aryl, optionally substituted heteroaryl, etc .; and R 2 2 represents H, lower alkyl, lower alkyl cycle, optionally substituted aryl, etc. Because of the high selectivity affinities with benzodiazepine receptors, these compounds are useful as benzodiazepine receptor agonists, specifically inverse agonists thereof, for example, brain activators and remedies for memory disorders associated with senile dementia, Alzheimer's, etc. |