| abstract |
TREATMENT OF INSULIN RESISTANCE WITH GROWTH HORMONE SECREGATES. This invention is directed to methods for treating insulin resistance in a mammal comprising administering to said mammal an effective amount of a compound of formula I, wherein the variables are defined in the specification, or the diastereomerically enriched stereoisomeric mixtures. pure, enantiomerically enriched or enantiomerically pure isomers, or pharmaceutically acceptable salts and prodrugs thereof. The compounds of formula I are growth hormone secretagogues and as such are useful for increasing the level of endogenous growth hormone. In another aspect this invention provides certain intermediates which are useful in the synthesis of said compounds and certain processes useful for the synthesis of said intermediates and compounds of formula I. This invention is further directed to methods comprising the functional administration of somatostatin such as an alpha agonist. Adrenergic and a compound of formula I. |