| abstract |
"PROCESSES FOR THE PREPARATION OF A COMPOUND AND FOR THE PREPARATION OF AN AMINO ALCOHOL". An efficient process for the preparation of key intermediates in the synthesis of (-) - 6-chloro-4-cyclopropylethyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxa zin-2-one, an inhibitor of reverse transcriptase, is achieved using a chiral addition reaction to 4-chloro-2-trifluoromethyl ketoaniline with an organozinc complex, to provide the desired alcohol. This current process has wide applicability in adding chiral to a proquiral ketone. |