| abstract |
<B> <MU> COMPOUNDS DERIVED FROM 24-NOR-SECOCOLA-5,7-DIENO, PREPARATION PROCESS, AND USE OF THE SAME <MV> <D> Derivatives of 24-nor-secocola-5,7- are exposed diene of formula (I) where A is a single or double bond, B is a CH ~ 2 ~ CH ~ 2 ~, CH-CH or C = C group, T is a CH ~ 2 ~ or CH ~ 2 ~ group CH ~ 2 ~, R ^ 1 ^ and R ^ 3 ^ are H or OH, C (R, R) and CH ~ 2 ~ or C = CH ~ 2 ~, R ^ 2 ^ is CH ~ 3 ~ and R ^ 4 ^ is H, or R ^ 2 ^ is H and R ^ 4 ^ is CH ~ 3 ~, L is phenyl and R ^ 5 ^ is OH or C (C ~ 1-4 ~ alkyl) ~ 2 ~ OH, or LR ^ 5 ^ is 2-furyl which is 5-substituted by C (C ~ 1-4 ~ -alkyl) ~ 2 ~, with the proviso that when L is phenyl, A is a single bond, B is C = C, T is CH ~ 2 ~, each R ^ 1 ^ and R ^ 2 ^ are OH, C (R, R) is C = CH ~ 2 ~, R ^ 2 ^ is CH ~ 3 ~, R ^ 4 ^ is H, and R ^ 5 ^ is C (CH ~ 3 ~) ~ 2 ~ OH, so R ^ 5 ^ should be in the ortho or para position, are useful in the treatment or prevention of vitamin D-dependent disorders, particularly psoriasis , basal cell carcinomas, keratinization and keratosis disorders, leukem ia, osteoporosis, hyperparathyroidism accompanied by renal failure, transplant rejection and graft against host disease. |