http://rdf.ncbi.nlm.nih.gov/pubchem/patent/BR-9809092-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c2b9dc89cc4ba060cc73bbf0c90bbb78 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D249-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-497 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D521-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-501 |
| filingDate | 1998-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eba079f32bcbec4cc344ea121dc53381 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_123b8ffcaf5460cda2002f105db51a95 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_123e73e40f33cd0f4b9dbb3faea3fa9d |
| publicationDate | 2002-01-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | BR-9809092-A |
| titleOfInvention | Indole derivatives having combined 5ht1a, 5ht1b and 5ht1d receptor antagonist activity |
| abstract | "INDOL DERIVATIVES HAVING COMBINED ACTIVITY OF 5HT1A, 5HT1B AND 5HT1D RECEPTOR ANTAGONIST". The present invention relates to compounds of formula (I), processes for their preparation and use as CNS agents, where R ^ a ^ is a group of formula (i), where P ^ 1 ^ is a phenyl , bicyclic aryl, a heterocyclic ring containing from 5 to 7 members containing from 1 to 3 heteroatoms selected from oxygen, nitrogen and sulfur, or a bicyclic heterocyclic ring containing from 1 to 3 heteroatoms selected from oxygen, nitrogen and sulfur; R ^ 1 ^ is hydrogen, halogen, C ~ 1-6 ~ alkyl, C ~ 3-6 ~ cycloalkyl, C ~ 1-6 ~ alkyl, C ~ 1-6 ~ alkoxy, hydroxy, C ~ 1-6 alkyl hydroxy ~, C ~ 1-6 ~ alkoxy hydroxide, C ~ 1-6 alkoxy, C ~ 1-6 ~ alkoxy, C ~ 1-6 ~ alkanoyl, nitro, methyl trifluor, cyano, SR ^ 9 ^, SOR ^ 9 ~ , SO ~ 2 ~ R ^ 9 ^, SO ~ 2 ~ NR ^ 10 ^ R ^ 11 ^, CO ~ 2 ~ R ^ 10 ^, CONR ^ 10 ^ R ^ 11 ^, CO ~ 2 ~ NR ^ 10 ^ R ^ 11 ^ CONR ^ 10 ^ (CH ~ 2 ~) ~ c ~ CO ~ 2 ~ R ^ 11 ^, (CH ~ 2 ~) ~ c ~ NR ^ 10 ^ R ^ 11 ^, (CH ~ 2 ~) ~ c ~ CONR ^ 10 ^ R ^ 11 ^, (CH ~ 2 ~) ~ c ~ NR ^ 10 ^ R ^ 11 ^, (CH ~ 2 ~) ~ c ~ CO ~ 2 ~ C ~ 1-6 ~ alkyl, CO ~ 2 ~ (CH ~ 2 ~) ~ c ~ OR ^ 10 ^, NR ^ 10 ^ OR ^ 11 ^, NR ^ 10 ^ CO ~ 2 ~ R ^ 11 ^, NR ^ 10 ^ CONR ^ 10 ^ R ^ 11 ^, CR ^ 11 ^ = NOR ^ 11 ^, NR ^ 10 ^ COOR ^ 11 ^, CNR ~ 10 ^ = NOR ^ 11 ^, where R ^ 10 ^ and R ^ 11 ^ are independently hydrogen or C ~ 1 alkyl -6 ~ ec is 1 to 4; R ^ 2 ^ is hydrogen, halogen, C ^ 1-6 ^ alkyl, C ~ 3-6 ~ cycloalkyl, C ~ 3-6 ~ cycloalkyl, C ~ 1-6 ~ alkoxy, acyl, aryl, acyloxy, hydroxy, nitro , trifluoromethyl, cyano, CO ~ 2 ~ R ^ 10 ^, CONR ^ 10 ^ R ^ 11 ^, NR ^ 10 ^ R ^ 11 ^, where R ^ 10 ^ and R ^ 11 ^ are as defined for R ^ 1 ^ ; a is 1, 2 or 3; or R ^ a ^ is a group of formula (ii), in which p ^ 2 ^ and P ^ 3 ^ are independently phenyl, bicyclic aryl, a 5- to 7-membered heterocyclic ring containing from 1 to 3 heteroatoms selected from oxygen, nitrogen and sulfur, or a bicyclic heterocyclic group containing from 1 to 3 heteroatoms selected from oxygen, nitrogen or sulfur; A is a bond or oxygen, S (O) ~ m ~ where m is 0 to 2, carbonyl, CH ~ 2 ~ or NR ^ 4 ^ ~ where R ^ 4 ^ is hydrogen or C ~ 1-6 ~ alkyl; R ^ 1 ^ is as defined above for formula (I) or R ^ 1 ^ is an optionally substituted 5- to 7-membered heterocyclic ring containing 1 to 3 selected heteroatoms of oxygen, nitrogen or sulfur; R ^ 2 ^ and R ^ 3 ^ are independently hydrogen, halogen, C ~ 1-6 ~ alkyl, C ~ 3-6 ~ cycloalkyl, C ~ 3-6 ~ cycloalkenyl, C ~ 1-6 ~ alkoxy, acyl, aryl , acyloxy, hydroxy, nitro, trifluoromethyl, cyano, CO ~ 2 ~ R ^ 10 ^, CONR ^ 10 ^ R ^ 11 ^, NR ^ 10 ^ R ^ 11 ^, where R ^ 10 ^ and R ^ 11 ^ are like defined for R ^ 1 ^; and a and b are, independently, 1, 2 or 3; Y is -NH-, NR ^ 5 ^, where R ^ 5 ^ is C ~ 1-6 ~ alkyl, or Y is -CH ~ 2 ~ or -O-; V is oxygen or sulfur; D is nitrogen, carbon or a CH group; W is (CR ^ 16 ^ R ^ 17 ^) ~ t ~, where t is 2, 3 or 4 and R ^ 16 ^ and R ^ 17 ^ are independently hydrogen or C ~ 1-6 ~ alkyl or W is (CR ^ 16 ~ R ~ 17 ~) ~ u ~ - J, where u is 0, 1, 2 or 3 and J is oxygen, sulfur, CR ^ 16 ^ = CR ^ 17 ^, CR ^ 16 ^ = N, = CR ^ 16 ^ O, = CR ^ 16 ^ S or = CR ^ 16 ^ -NR ^ 17 ^; X is nitrogen or carbon; R ^ b ^ is hydrogen, halogen, hydroxy, C ~ 1-6 ~ alkyl, trifluoromethyl, C ~ 1-6 ~ alkoxy, C ~ 2-6 ~ alkenyl, C ~ 3-7 ~ cycloalkyl optionally substituted by C ~ alkyl 1-4 ~ or aryl; R ^ c ^ is hydrogen or C ~ 1-6 ~ alkyl; and <sym> is a single bond when X is nitrogen or a single or double bond when X is carbon. |
| priorityDate | 1997-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 61.