http://rdf.ncbi.nlm.nih.gov/pubchem/patent/BR-9804648-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2d6eb785a13032f52d1f7f654acac96d |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10T436-142222 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10T436-145555 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10T436-141111 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10T436-147777 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10T436-25125 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10T436-25375 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-9446 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-94 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-94 |
| filingDate | 1998-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c09167fe3799abf0cfc78bd258028ed1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d6ef0bbe57b36e6ed2809736437410c2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_480f64197b4d749a0d50afac9de3696f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a8a901e17b65bec211edc572cb6c6141 |
| publicationDate | 2000-05-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | BR-9804648-A |
| titleOfInvention | Monitoring of patient compliance with treatment and bioavailability of drugs by deproteinization of body fluids. |
| abstract | <B> MONITORING OF PATIENT'S OBEDIENCE TO TREATMENT AND DRUG BIOAVAILABILITY BY DEPROTEINIZATION OF BODY FLUIDS <D>. The objective of the present invention is to provide a method of quantitative determination of the concentration of drugs present in body fluids in order to monitor both compliance with treatment with the prescribed medication and the levels of the drug practiced in individual clinical treatment and in Public Health programs . Monitoring of drug levels is achieved through quantitative assays that allow the detection of drugs present in body fluids in concentrations below 0.3 <109> g / ml. The method is characterized by a previous deproteinization step which provides for the recovery of at least 97% of the amount of the substance under analysis present in the body fluid, that is, by doing deproteinization in the presence of ZnSO ~ 4 ~ it is possible to efficiently remove , the drug that has stuck to the proteins contained in the body fluid. It should be noted that the method of the invention is especially useful in determining the drug present in the blood as it contains much more protein than other biological fluids such as urine, saliva or tear fluid. An embodiment of the present invention is a method for determining the level of the drug using a simplified and effective step of deproteinization from bodily fluids, such as plasma, blood, urine, saliva or tear fluid followed by the extraction of the drug and its quantification using an accurate technique, such as colorimetric and HPLC tests. A particular embodiment relates to a method for quantifying rifampicin for the purpose of monitoring the levels of that drug in body fluids as well as a tuberculosis treatment monitoring kit based on determining the concentration of rifampicin in body fluids. |
| priorityDate | 1998-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
| Predicate | Subject |
|---|---|
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID431847471 http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID135900090 |
Total number of triples: 23.