| abstract |
Invention Patent: <B> "SUBSTITUTED ISOQUINOLINE-3-CARBOXAMIDES, THEIR PREPARATION AND USE AS PHARMACEUTICAL SUBSTANCES" <D>. The isoquinoline-3-carboxamides of formula I where R ~ 1 ~ is hydrogen or chlorine, R² is hydrogen, alkyl, alkoxy, chlorine, trifluoromethyl, hydroxyl, or benzyloxy, which is optionally substituted, or fluoraloxyoxy of the formula O- [ CH ~ 2 ~] ~ x ~ -C ~ f ~ H ~ (2f + 1-g) ~ F ~ g ~, where x = 0 or 1, f = 1 - 5 and g = 1 a (2f + 1), R³ is hydrogen, alkyl, alkoxy, fluorine, chlorine, cyano, trifluoromethyl, hydroxyl, or benzyloxy, which is optionally substituted, or fluoraloxycoxy of the formula described above, R ^ 4 ^ and R ^ 5 ^ are hydrogen, alkyl, fluorine, chlorine, bromine, trifluoromethyl, cyano, alkoxy, or fluoralkoxyoxy of the formula described above, including the physiologically active salts, are strong inhibitors of prolyl-4-hydroxylase, which do not cause steatosis. |