| abstract |
"CEPHALOSPORIN DERIVATIVES". They are provided with cephe represented by the general formula (I) in which Q is an optionally substituted pyridinium group attached to the sulfur atom via a ring carbon atom; X is halogen; Y is hydrogen or halogen; L ^ 1 ^ is a furan group, a thiophene group, a C ~ 2 ~ -10 ~ alkyl group, or a C ~ 2-10 ~ alkyl group interrupted with one or more groups independently selected from vinyl, S, SO, SO ~ 2 ~, SO ~ 2 ~ NH (IIa), (IIb); n is 0 or 1; A is CO ~ 2 ~ H, PO ~ 3 ~ H ~ 2 ~, SOP ~ 3 ~ H, or tetrazole; and R ^ 1 ^ is hydrogen or a carboxyl protecting group; and pharmaceutically acceptable salts and / or prodrugs thereof. Derivatives are gram-positive antibacterial agents, especially useful in the treatment of diseases caused by methicillin-resistant Staphylococus aureus (MRSA). |